Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Creutzfeldt-Jakob disease causes

Introduction

Overview

Overview

Creutzfeldt-Jakob disease is caused by the presence of a prion protein, an abnormal isoform of a cellular glycoprotein. Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrPSc). The normal, cellular PrP (PrPC) is converted into PrPSc through a posttranslational process during which it acquires a high beta-sheet content.

Causes

Causes

  • Creutzfeldt-Jakob disease is caused by the presence of a prion protein, an abnormal isoform of a cellular glycoprotein.[1]
  • Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrPSc). The normal, cellular PrP (PrPC) is converted into PrPSc through a posttranslational process during which it acquires a high beta-sheet content.[2]
References

References

  1. ↑ “http://www.cdc.gov/ncidod/dvrd/cjd/qa_cjd_infection_control.htm#what”. Retrieved 14 February 2014. External link in |title= (help)
  2. ↑ Prusiner SB (1998). “Prions”. Proc Natl Acad Sci U S A. 95 (23): 13363–83. PMC 33918. PMID 9811807.

Template:WikiDoc Sources

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: , Mohamadmostafa Jahansouz M.D.[2]