• Patients with Creutzfeldt-Jakob disease usually appear confused.

• Vital Signs of patients with Creutzfeldt-Jakob disease are usually normal.

• Skin examination of patients with Creutzfeldt-Jakob disease is usually normal.

• HEENT examination of patients with Creutzfeldt-Jakob disease is usually normal.

• Neck examination of patients with Creutzfeldt-Jakob disease is usually normal.

• Pulmonary examination of patients with Creutzfeldt-Jakob disease is usually normal.

• Cardiovascular examination of patients with Creutzfeldt-Jakob disease is usually normal.

• Abdominal examination of patients with Creutzfeldt-Jakob disease is usually normal.

• Back examination of patients with Creutzfeldt-Jakob disease is usually normal.

• Genitourinary examination of patients with Creutzfeldt-Jakob disease is usually normal.

Physical examination of patients with Creutzfeldt-Jakob disease is usually remarkable for:^{[1][2][3][4][5]}

• Speech impairment
• Myoclonus
• Ataxia
• Gait disturbances
• Rigid posture
• Dysarthria
• Myoclonus

• Visual changes leading to cortical blindness
• Akinetic mutism in the last stages of the disease
• Chorea
• Peripheral neuropathy
• Altered mental status

Myoclonus is the most common sign in patients Creutzfeldt-Jakob disease.

Patient is usually disoriented to persons, place, and time.

• Extremities examination of patients with Creutzfeldt-Jakob disease is usually normal.