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Cryoglobulinemia historical perspective

Introduction

Overview

Overview

In 1966, Meltzer and Franklin were the first ones to describe Meltzer triad which includes following clinical manifestations, purpura, arthralgia, and weakness.

Historical Perspective

Historical Perspective

The historical perspective of cryoglobulinemia is as follows:[1][2]

  • In 1966, Meltzer and Franklin were the first ones to describe Meltzer triad which includes following clinical manifestations, purpura, arthralgia, and weakness.
  • This triad of clinical manifestations was seen in the patients having essential mixed cryoglobulinemia.
References

References

  1. ↑ Meltzer M, Franklin EC, Elias K, McCluskey RT, Cooper N (1966). “Cryoglobulinemia–a clinical and laboratory study. II. Cryoglobulins with rheumatoid factor activity”. Am J Med. 40 (6): 837–56. PMID 4956871.
  2. ↑ Monti G, Galli M, Invernizzi F, Pioltelli P, Saccardo F, Monteverde A; et al. (1995). “Cryoglobulinaemias: a multi-centre study of the early clinical and laboratory manifestations of primary and secondary disease. GISC. Italian Group for the Study of Cryoglobulinaemias”. QJM. 88 (2): 115–26. PMID 7704562.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Feham Tariq, MD [2]