Cryoglobulinemia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]Feham Tariq, MD [3]

Overview

Patients having cryoglobulinemia may have positive history of hepatitis C infection, hepatitis B infection, leg ulcers or recurrent thrombosis. Symptoms vary depending on the type of cryoglobulinemia and the organs involved.

History

Patients having cryoglobulinemia may have positive history of:

Hepatitis C infection
Hepatitis B infection
Leg ulcers
Recurrent thrombosis

Symptoms

Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include:^[1]^[2]^[3]

Pulmonary symptoms:

Difficulty breathing and cough

Renal symptoms:

Renal involvement is more common in type II than in type III.
Nephrotic range proteinuria with edema

Cutaneous symptoms:

Purpura or skin ulcer

Gastrointestinal symptoms

Abdominal pain

General symptoms:

Nonspecific constitutional symptoms
Fever
Arthralgia, specifically affecting metacarophangeal, proximal phalangeal, knees and ankles. It worsens with exposure to the cold.
Myalgia
Fatigue

Blurring/loss of vision
Diplopia
Confusion

References

↑ Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M (1974). “Biologic and clinical significance of cryoglobulins. A report of 86 cases”. Am J Med. 57 (5): 775–88. PMID 4216269.
↑ Monti G, Galli M, Invernizzi F, Pioltelli P, Saccardo F, Monteverde A; et al. (1995). “Cryoglobulinaemias: a multi-centre study of the early clinical and laboratory manifestations of primary and secondary disease. GISC. Italian Group for the Study of Cryoglobulinaemias”. QJM. 88 (2): 115–26. PMID 7704562.
↑ Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J (2000). “Mixed cryoglobulinemia: new concepts”. Lupus. 9 (2): 83–91. doi:10.1191/096120300678828127. PMID 10787003.

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[pmid4216269-1] Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M (1974). “Biologic and clinical significance of cryoglobulins. A report of 86 cases”. Am J Med. 57 (5): 775–88. PMID 4216269.

[pmid7704562-2] Monti G, Galli M, Invernizzi F, Pioltelli P, Saccardo F, Monteverde A; et al. (1995). “Cryoglobulinaemias: a multi-centre study of the early clinical and laboratory manifestations of primary and secondary disease. GISC. Italian Group for the Study of Cryoglobulinaemias”. QJM. 88 (2): 115–26. PMID 7704562.

[pmid10787003-3] Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J (2000). “Mixed cryoglobulinemia: new concepts”. Lupus. 9 (2): 83–91. doi:10.1191/096120300678828127. PMID 10787003.

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