Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Cryoglobulinemia history and symptoms
Introduction
Overview
Overview
Patients having cryoglobulinemia may have positive history of hepatitis C infection, hepatitis B infection, leg ulcers or recurrent thrombosis. Symptoms vary depending on the type of cryoglobulinemia and the organs involved.
History
History
Patients having cryoglobulinemia may have positive history of:
- Hepatitis C infection
- Hepatitis B infection
- Leg ulcers
- Recurrent thrombosis
Symptoms
Symptoms
Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include:[1][2][3]
Pulmonary symptoms:
- Difficulty breathing and cough
Renal symptoms:
- Renal involvement is more common in type II than in type III.
- Nephrotic range proteinuria with edema
Cutaneous symptoms:
Gastrointestinal symptoms
- Abdominal pain
General symptoms:
- Nonspecific constitutional symptoms
- Fever
- Arthralgia, specifically affecting metacarophangeal, proximal phalangeal, knees and ankles. It worsens with exposure to the cold.
- Myalgia
- Fatigue
References
References
- ↑ Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M (1974). “Biologic and clinical significance of cryoglobulins. A report of 86 cases”. Am J Med. 57 (5): 775–88. PMID 4216269.
- ↑ Monti G, Galli M, Invernizzi F, Pioltelli P, Saccardo F, Monteverde A; et al. (1995). “Cryoglobulinaemias: a multi-centre study of the early clinical and laboratory manifestations of primary and secondary disease. GISC. Italian Group for the Study of Cryoglobulinaemias”. QJM. 88 (2): 115–26. PMID 7704562.
- ↑ Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J (2000). “Mixed cryoglobulinemia: new concepts”. Lupus. 9 (2): 83–91. doi:10.1191/096120300678828127. PMID 10787003.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]Feham Tariq, MD [3]