Cryoglobulinemia natural history, complications and prognosis

The complications of cryoglobulinemia are as follows:

• Rapidly progressive neuropathy
• Heart failure
• Digital ischemia threatening amputation
• Diffuse alveolar hemorrhage resulting in hemoptysis
• Respiratory failure
• Stroke
• End stage renal disease

Patients having severe manifestations of the disease such as pulmonary vasculitis, end-stage renal disease, cardiac vasculitis and central nervous system vasculitis have generally poor prognosis of the disease. The prognosis of cryoglobulinemia depends on the organ system involved and varies accordingly.

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