Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Cryoglobulinemia other diagnostic studies
Introduction
Overview
Overview
Skin biopsy can be of value in establishing the diagnosis. The characteristic findings on renal biopsy may include intraluminal thrombi, diffuse IgM deposition in the capillary loops and subendothelial deposits in a “curvilinear” pattern on EM.
Other Diagnostic Studies
Other Diagnostic Studies
Skin Biopsy
Skin biopsy can be of value in establishing the diagnosis.
Renal Biopsy
- The characteristic findings on renal biopsy are:[1][2]
- Intraluminal thrombi
- Diffuse IgM deposition in the capillary loops
- Subendothelial deposits in a “curvilinear” pattern on EM.
- Only 14% develop end stage renal disease (ESRD) at 10 years after a renal biopsy demonstrates MC.
- Recurrent MC can affect up to 70% of transplanted kidneys, but does not preclude transplantation since most of these grafts do not fail.
References
References
- ↑ D’Amico G, Colasanti G, Ferrario F, Sinico RA (April 1989). “Renal involvement in essential mixed cryoglobulinemia”. Kidney Int. 35 (4): 1004–14. PMID 2651764.
- ↑ Sinico RA, Winearls CG, Sabadini E, Fornasieri A, Castiglione A, D’Amico G (July 1988). “Identification of glomerular immune deposits in cryoglobulinemia glomerulonephritis”. Kidney Int. 34 (1): 109–16. PMID 3050245.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Feham Tariq, MD [2] Cafer Zorkun, M.D., Ph.D. [3]