Cryoglobulinemia other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Feham Tariq, MD [2] Cafer Zorkun, M.D., Ph.D. [3]

Overview

Skin biopsy can be of value in establishing the diagnosis. The characteristic findings on renal biopsy may include intraluminal thrombi, diffuse IgM deposition in the capillary loops and subendothelial deposits in a “curvilinear” pattern on EM.

Other Diagnostic Studies

Skin Biopsy

Skin biopsy can be of value in establishing the diagnosis.

Renal Biopsy

The characteristic findings on renal biopsy are:^[1]^[2]
1. Intraluminal thrombi
2. Diffuse IgM deposition in the capillary loops
3. Subendothelial deposits in a “curvilinear” pattern on EM.
Only 14% develop end stage renal disease (ESRD) at 10 years after a renal biopsy demonstrates MC.
Recurrent MC can affect up to 70% of transplanted kidneys, but does not preclude transplantation since most of these grafts do not fail.

References

↑ D’Amico G, Colasanti G, Ferrario F, Sinico RA (April 1989). “Renal involvement in essential mixed cryoglobulinemia”. Kidney Int. 35 (4): 1004–14. PMID 2651764.
↑ Sinico RA, Winearls CG, Sabadini E, Fornasieri A, Castiglione A, D’Amico G (July 1988). “Identification of glomerular immune deposits in cryoglobulinemia glomerulonephritis”. Kidney Int. 34 (1): 109–16. PMID 3050245.

Template:WikiDoc Sources

[pmid2651764-1] D’Amico G, Colasanti G, Ferrario F, Sinico RA (April 1989). “Renal involvement in essential mixed cryoglobulinemia”. Kidney Int. 35 (4): 1004–14. PMID 2651764.

[pmid3050245-2] Sinico RA, Winearls CG, Sabadini E, Fornasieri A, Castiglione A, D’Amico G (July 1988). “Identification of glomerular immune deposits in cryoglobulinemia glomerulonephritis”. Kidney Int. 34 (1): 109–16. PMID 3050245.

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