Patients with Cushing’s syndrome usually appear obese. Physical examination of patients with Cushing’s syndrome is remarkable for moon-like facies, easy bruising, purple skin striae, and hirsutism.

Physical examination of patients with Cushing’s syndrome is as follows:^[1]

• Patients with Cushing’s syndrome are usually overweight.

• Hypertension, due to cortisol’s enhancement of epinephrine‘s vasoconstrictive effect.

• Moon-face is a medical sign where the face swells up into a rounded shape. It is often associated with Cushing’s syndrome, which has led to it being known as Cushingoid facies (“Cushings-like face”), or steroid treatment, which has led to the name steroid facies.

• Hyperpigmentation – this is due to melanocyte stimulating hormone (MSH) production, as a byproduct of ACTH synthesis from Proopiomelanocortin (POMC)
• Telangiectasia (dilation of capillaries)
• Thinning of the skin (which causes easy bruising)
• Purple or red striae (the weight gain in Cushing’s stretches the skin, which is thin and weakened, causing it to hemorrhage) on the trunk, buttocks, arms, legs or breasts, proximal muscle weakness (hips, shoulders)
• Hirsutism (facial male-pattern hair growth)

• Bitemporal hemianopsia – pituitary lesion may cause compression of the optic chiasm.

• Growth of fat pads along the collar bone and on the back of the neck (known as lipodystrophy).