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DAF-16-associated element gene transcriptions

Introduction

Associate Editor(s)-in-Chief: Henry A. Hoff

“DAF-16 binding element (DBE), GTAAACA or TGTTTAC, and DAF-16-associated element (DAE), TGATAAG or CTTATCA, enriched in DAF-16 regulated genes [2, 4, 13, 14]. The DBE was recognized by DAF-16, and the DAE by transcription factor PQM-1 [13].”[1] Note: GTAAACA is the inverse complement (ic) of TGTTTAC and TGATAAG is the ic of CTTATCA.

Consensus sequences

Consensus sequences

Main article: Consensus sequence gene transcriptions

5′-TGATAAG-3′.[1]

Hypotheses

Hypotheses

Main article: Hypotheses
  1. A1BG has no DAF-16-associated elements in either promoter.
  2. A1BG is not transcribed by a DAF-16-associated element.
  3. DAF-16-associated element does not participate in the transcription of A1BG.
Samplings

Samplings

Main article: Model samplings

Samplings

Copying the consensus sequence 5′-TGATAAG-3′ into ⌘F has found no elements in either A1BG promoter.

For the Basic programs testing consensus sequence 5′-TGATAAG-3′ (starting with SuccessablesAAA.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

  1. negative strand, negative direction, looking for 5′-TGATAAG-3′, 0.
  2. negative strand, positive direction, looking for 5′-TGATAAG-3′, 0.
  3. positive strand, negative direction, looking for 5′-TGATAAG-3′, 0.
  4. positive strand, positive direction, looking for 5′-TGATAAG-3′, 0.
  5. complement, negative strand, negative direction, looking for 5′-ACTATTC-3′, 0.
  6. complement, negative strand, positive direction, looking for 5′-ACTATTC-3′, 0.
  7. complement, positive strand, negative direction, looking for 5′-ACTATTC-3′, 0.
  8. complement, positive strand, positive direction, looking for 5′-ACTATTC-3′, 0.
  9. inverse complement, negative strand, negative direction, looking for 5′-CTTATCA-3′, 0.
  10. inverse complement, negative strand, positive direction, looking for 5′-CTTATCA-3′, 0.
  11. inverse complement, positive strand, negative direction, looking for 5′-CTTATCA-3′, 0.
  12. inverse complement, positive strand, positive direction, looking for 5′-CTTATCA-3′, 0.
  13. inverse negative strand, negative direction, looking for 5′-GAATAGT-3′, 0.
  14. inverse negative strand, positive direction, looking for 5′-GAATAGT-3′, 0.
  15. inverse positive strand, negative direction, looking for 5′-GAATAGT-3′, 0.
  16. inverse positive strand, positive direction, looking for 5′-GAATAGT-3′, 0.
Acknowledgements

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

See also

See also

References

References

  1. ↑ 1.0 1.1 Yan-Hui Li and Gai-Gai Zhang (12 April 2016). “Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans“. Oncotarget. 7 (15): 19185–19192. doi:10.18632/oncotarget.8313. PMID 2702736. Retrieved 27 August 2020.
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