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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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DIPSS Plus Score

Introduction

Overview

Overview

Dynamic International Prognostic Scoring System (DIPSS)‐plus scoring system comprises of eight risk variables to predict the prognosis in myelofibrosis.

DIPSS Plus Score Calculator

DIPSS Plus Score Calculator

DIPSS plus score for prognosis in myelofibrosis

  • This handy calculator computes the prognosis in myelofibrosis using Dynamic International Prognostic Scoring System (DIPSS)‐plus. This scoring system comprises of eight risk variables.[1][2]

Check all boxes that apply to your patient:

DIPSS Plus Score for Prognosis in Myelofibrosis
Variable Score
Age >65 years 1
Constitutional symptoms 1
Hemoglobin <10 g/dL 1
Leucocyte count >25 x 10⁹/L 1
Circulating blasts ≥1% 1
Unfavourable karyotype (complex karyotype or abnormalities that include +8, -7/7q-, i(17q), inv(3), 5/5q-, 12p-, or 11q23 rearrangement) 1
Transfusion dependency 1
Platelet count <100 x 10⁹/L 1
DIPSS Plus Score:
Interpretation:

Interpretation of DIPSS plus score

  • Score = 0: Low risk group; estimated median survival is approximately 15.4 years
  • Score = 1: Intermediate-1 risk group; estimated median survival is approximately 6.5 years
  • Score = 2 or 3: Intermediate-2 risk group; estimated median survival is approximately 2.9 years
  • Score ≥ 4: High risk group; estimated median survival is approximately 1.3 years
References

References

  1. ↑ Gangat N, Caramazza D, Vaidya R, George G, Begna K, Schwager S, Van Dyke D, Hanson C, Wu W, Pardanani A, Cervantes F, Passamonti F, Tefferi A (February 2011). “DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status”. J. Clin. Oncol. 29 (4): 392–7. doi:10.1200/JCO.2010.32.2446. PMID 21149668.
  2. ↑ Bose P, Verstovsek S (August 2016). “Prognosis of Primary Myelofibrosis in the Genomic Era”. Clin Lymphoma Myeloma Leuk. 16 Suppl: S105–13. doi:10.1016/j.clml.2016.02.031. PMC 4987499. PMID 27521306.

Editor-In-Chief:
C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]