Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
DPPA3
Introduction
Developmental pluripotency-associated protein 3 is a protein that in humans is encoded by the DPPA3 gene.[1]
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.[1]
Further reading
Further reading
- Nakamura T, Arai Y, Umehara H, et al. (2007). “PGC7/Stella protects against DNA demethylation in early embryogenesis”. Nat. Cell Biol. 9 (1): 64–71. doi:10.1038/ncb1519. PMID 17143267.
- Elliman SJ, Wu I, Kemp DM (2006). “Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin”. J. Biol. Chem. 281 (1): 16–9. doi:10.1074/jbc.C500415200. PMID 16291741.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Bortvin A, Goodheart M, Liao M, Page DC (2004). “Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice”. BMC Dev. Biol. 4: 2. doi:10.1186/1471-213X-4-2. PMCÂ 362866. PMIDÂ 15018652.
- Clark AT, Rodriguez RT, Bodnar MS, et al. (2004). “Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma”. Stem Cells. 22 (2): 169–79. doi:10.1634/stemcells.22-2-169. PMID 14990856.
- Bowles J, Teasdale RP, James K, Koopman P (2004). “Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours”. Cytogenet. Genome Res. 101 (3–4): 261–5. doi:10.1159/000074346. PMID 14684992.
- Payer B, Saitou M, Barton SC, et al. (2004). “Stella is a maternal effect gene required for normal early development in mice”. Curr. Biol. 13 (23): 2110–7. doi:10.1016/j.cub.2003.11.026. PMID 14654002.
- Sato M, Kimura T, Kurokawa K, et al. (2002). “Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells”. Mech. Dev. 113 (1): 91–4. doi:10.1016/S0925-4773(02)00002-3. PMID 11900980.