Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Danaparoid
Introduction
Overview
Overview
Danaparoid sodium (Orgaran®) is an anticoagulant that works by inhibiting activated factor X (factor Xa).
Danaparoid is considered a “low molecular weight heparin” by some sources, but is chemically distinct from heparin and thus has little cross-reactivity in heparin-intolerant patients.
Uses
Uses
It is used to prevent deep venous clots, particularly in situations with a high risk of clot formation, such as after hip surgery.
It is also used as a heparinoid substitute in heparin-induced thrombocytopenia which may otherwise cause paradoxical thrombosis.
Discontinuation
Discontinuation
On August 14, 2002, this drug was withdrawn by Organon International.[1]
Side Effects
Side Effects
- Bleeding problems
- Low platelets, due to a low level of structural similarity between danaparoid and heparin
- Asthma exacerbations, due to allergies to sulphites contained within the medicine
External Links
External Links
- danaparoid at the US National Library of Medicine Medical Subject Headings (MeSH)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]