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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Delirium future or investigational therapies

Introduction

Overview

Overview

There are many still unknowns about delirium. Studies are being conducted to understand pathophysiology, more effective ways of prevention, utilization of EEG and CT/MRI scan, etc.

Future or Investigational Therapies

Future or Investigational Therapies

Currently many studies are being conducted such as;

Prevention of Delirium

Studies to Improve Diagnosis and Prevention of Delirium

Studies to Understand Pathophysiology of Delirium

References

References

  1. ↑ Grover, Sandeep; Dua, Devakshi; Sahoo, Swapnajeet; Chakrabarti, Subho; Avasthi, Ajit (2019). “Effectiveness of melatonin in the management of delirium: A retrospective study”. Journal of Mental Health and Human Behaviour. 24 (2): 78. doi:10.4103/jmhhb.jmhhb_56_19. ISSN 0971-8990.
  2. ↑ Nishikimi, Mitsuaki; Numaguchi, Atsushi; Takahashi, Kunihiko; Miyagawa, Yasuhiro; Matsui, Kota; Higashi, Michiko; Makishi, Go; Matsui, Shigeyuki; Matsuda, Naoyuki (2018). “Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU”. Critical Care Medicine. 46 (7): 1099–1105. doi:10.1097/CCM.0000000000003132. ISSN 0090-3493.
  3. ↑ Ng, K. T.; Shubash, C. J.; Chong, J. S. (2019). “The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis”. Anaesthesia. 74 (3): 380–392. doi:10.1111/anae.14472. ISSN 0003-2409.
  4. ↑ Soh, Sarah; Shim, Jae-Kwang; Song, Jong-Wook; Choi, Nakcheoul; Kwak, Young-Lan (2019). “Preoperative transcranial Doppler and cerebral oximetry as predictors of delirium following valvular heart surgery: a case–control study”. Journal of Clinical Monitoring and Computing. 34 (4): 715–723. doi:10.1007/s10877-019-00385-x. ISSN 1387-1307.
  5. ↑ Nitchingham, Anita; Kumar, Varun; Shenkin, Susan; Ferguson, Karen J.; Caplan, Gideon A. (2018). “A systematic review of neuroimaging in delirium: predictors, correlates and consequences”. International Journal of Geriatric Psychiatry. 33 (11): 1458–1478. doi:10.1002/gps.4724. ISSN 0885-6230.
  6. ↑ Kimchi, Eyal Y.; Neelagiri, Anudeepthi; Whitt, Wade; Sagi, Avinash Rao; Ryan, Sophia L.; Gadbois, Greta; Groothuysen, Daniël; Westover, M. Brandon (2019). “Clinical EEG slowing correlates with delirium severity and predicts poor clinical outcomes”. Neurology. 93 (13): e1260–e1271. doi:10.1212/WNL.0000000000008164. ISSN 0028-3878.
  7. ↑ Wang, Ping; Velagapudi, Ravikanth; Kong, Cuicui; Rodriguiz, Ramona M.; Wetsel, William C.; Yang, Ting; Berger, Miles; Gelbard, Harris A.; Colton, Carol A.; Terrando, Niccolò (2020). “Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia”. Alzheimer’s & Dementia. 16 (5): 734–749. doi:10.1002/alz.12064. ISSN 1552-5260.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Pratik Bahekar, MBBS [3]