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Demeclocycline hydrochloride description

Demeclocycline hydrochloride
DEMECLOCYCLINE HYDROCHLORIDE® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Description

Description

Demeclocycline hydrochloride is an antibiotic isolated from a mutant strain of Streptomyces aureofaciens. Chemically it is 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12, 12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride. The structural formula is:

The molecular weight is 501.32 and the empirical formula is C21H21CIN2O8•HCI.

Each film-coated tablet contains demeclocycline hydrochloride 150 mg or 300 mg. In addition, each tablet contains the following inactive ingredients: alginic acid, colloidal silicon dioxide, crosscarmellose sodium, lactose monohydrate, microcrystalline cellulose, magnesium stearate, and povidone. The film coating material, contains FD&C Red #40, hypromellose 3cP, hypromellose 6cP, hypromellose 50cP, macrogol, polydextrose, titanium dioxide and triacetin.[1]

References

References

Adapted from the FDA Package Insert.

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