Denaverine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during childbirth.^[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.^[2]

Mechanism of action

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.^[3]

References

↑ Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
↑ Dootz, H; Kuhlmann, A; Hoffmann, K (eds.). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.
↑ Dinnendahl, V, Fricke, U, ed. (2010). Arzneistoff-Profile (in German). 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.

[1] Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report

[2] Dootz, H; Kuhlmann, A; Hoffmann, K (eds.). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.

[Arzneistoff-Profile-3] Dinnendahl, V, Fricke, U, ed. (2010). Arzneistoff-Profile (in German). 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.

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Denaverine

Overview

Mechanism of action

References

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