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Deoxyribonuclease ii, lysosomal
Introduction
Deoxyribonuclease II, lysosomal is a protein that in humans is encoded by the DNASE2 gene. [1]
Function
Function
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.
Further reading
Further reading
- Chou SF, Chen HL, Lu SC (2002). “Up-regulation of human deoxyribonuclease II gene expression during myelomonocytic differentiation of HL-60 and THP-1 cells”. Biochem. Biophys. Res. Commun. 296 (1): 48–53. doi:10.1016/s0006-291x(02)00835-5. PMID 12147225.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.