Desmoid tumor epidemiology and demographics

Desmoid tumor accounts for 0.03% of all tumors and less than 3% of all the soft tissue tumors. It affects 1 to 2 per 500,000 people worldwide. Incidence of desmoid tumor is approximately two to four per million population per year in general population. Familial desmoids are present in 10% to 25% of FAP patients. Gender ratio is 2:1 for females to males and commonly affects individuals between 20 to 60 years of age.

• The incidence of desmoid tumor is approximately 0/2-0/4 per 100,000 population per year in general population.^[1][2]

• Desmoid tumor accounts for approximately 0.03 percent of all neoplasms
• It accounts for less than 3% of all the soft tissue tumors
• Affects 1 to 2 per 500,000 people worldwide
• In the United States, 900 to 1,500 new cases are diagnosed per year
• Sporadic desmoid tumors are more common than familial desmoids associated with familial adenomatous polyposis
• Familial desmoid tumor (germline APC mutation) occurs in 10% to 25% of FAP patients^[3][4]
• People with germline APC mutation have 850 times greater risk of developing desmoids than the general population^[5]
• Sporadic desmoids (APC or the beta-catenin gene mutations) are relatively rare, affect 2 to 5 individuals per million per year in the general population^[6][7][8][9]

• Female are more commonly affected by desmoid tumor than male.^[10]
• The female of fertile age to male ratio is approximately 2:1.
• Incidence is the same in both genders in children.

• Desmoid tumor commonly affects individuals between 20 to 60 years of age.^[2][11]
• Desmoid tomur commonly affects 30 to 40 years.

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