
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Desmoid tumor epidemiology and demographics
Introduction
Overview
Overview
Desmoid tumor accounts for 0.03% of all tumors and less than 3% of all the soft tissue tumors. It affects 1 to 2 per 500,000 people worldwide. Incidence of desmoid tumor is approximately two to four per million population per year in general population. Familial desmoids are present in 10% to 25% of FAP patients. Gender ratio is 2:1 for females to males and commonly affects individuals between 20 to 60 years of age.
Epidemiology and Demographics
Epidemiology and Demographics
Incidence
- The incidence of desmoid tumor is approximately 0/2-0/4 per 100,000 population per year in general population.[1][2]
Prevalence
- Desmoid tumor accounts for approximately 0.03 percent of all neoplasms
- It accounts for less than 3% of all the soft tissue tumors
- Affects 1 to 2 per 500,000 people worldwide
- In the United States, 900 to 1,500 new cases are diagnosed per year
- Sporadic desmoid tumors are more common than familial desmoids associated with familial adenomatous polyposis
- Familial desmoid tumor (germline APC mutation) occurs in 10% to 25% of FAP patients[3][4]
- People with germline APC mutation have 850 times greater risk of developing desmoids than the general population[5]
- Sporadic desmoids (APC or the beta-catenin gene mutations) are relatively rare, affect 2 to 5 individuals per million per year in the general population[6][7][8][9]
Gender
- Female are more commonly affected by desmoid tumor than male.[10]
- The female of fertile age to male ratio is approximately 2:1.
- Incidence is the same in both genders in children.
Age
- Desmoid tumor commonly affects individuals between 20 to 60 years of age.[2][11]
- Desmoid tomur commonly affects 30 to 40 years.
Reference
Reference
- ↑ Reitamo JJ, Häyry P, Nykyri E, Saxén E (1982). “The desmoid tumor. I. Incidence, sex-, age- and anatomical distribution in the Finnish population”. Am J Clin Pathol. 77 (6): 665–73. PMID 7091046.
- ↑ 2.0 2.1 Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016
- ↑ Bertario L, Russo A, Sala P, Eboli M, Giarola M, D’amico F; et al. (2001). “Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis”. Int J Cancer. 95 (2): 102–7. PMID 11241320.
- ↑ Friedl W, Caspari R, Sengteller M, Uhlhaas S, Lamberti C, Jungck M; et al. (2001). “Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families”. Gut. 48 (4): 515–21. PMC 1728231. PMID 11247896.
- ↑ Ferenc T, Sygut J, KopczyÅ„ski J, Mayer M, Latos-BieleÅ„ska A, Dziki A; et al. (2006). “Aggressive fibromatosis (desmoid tumors): definition, occurrence, pathology, diagnostic problems, clinical behavior, genetic background”. Pol J Pathol. 57 (1): 5–15. PMID 16739877.
- ↑ Leal RF, Silva PV, Ayrizono Mde L, Fagundes JJ, Amstalden EM, Coy CS (2010). “Desmoid tumor in patients with familial adenomatous polyposis”. Arq Gastroenterol. 47 (4): 373–8. PMID 21225148.
- ↑ Fisher C, Thway K (2014). “Aggressive fibromatosis”. Pathology. 46 (2): 135–40. doi:10.1097/PAT.0000000000000045. PMID 24378386.
- ↑ Schiessling S, Kihm M, Ganschow P, Kadmon G, Büchler MW, Kadmon M (2013). “Desmoid tumour biology in patients with familial adenomatous polyposis coli”. Br J Surg. 100 (5): 694–703. doi:10.1002/bjs.9053. PMID 23334997.
- ↑ Fallen T, Wilson M, Morlan B, Lindor NM (2006). “Desmoid tumors — a characterization of patients seen at Mayo Clinic 1976-1999”. Fam Cancer. 5 (2): 191–4. doi:10.1007/s10689-005-5959-5. PMID 16736290.
- ↑ Mankin HJ, Hornicek FJ, Springfield DS (2010). “Extra-abdominal desmoid tumors: a report of 234 cases”. J Surg Oncol. 102 (5): 380–4. doi:10.1002/jso.21433. PMID 19877160.
- ↑ Economou, Athanasios; Pitta, Xanthi; Andreadis, Efstathios; Papapavlou, Leonidas; Chrissidis, Thomas (2011). “Desmoid tumor of the abdominal wall: a case report”. Journal of Medical Case Reports. 5 (1): 326. doi:10.1186/1752-1947-5-326. ISSN 1752-1947.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
