Detoxication

The major metabolites formed from most drug metabolism are detoxication products. There are two common patterns observed:

1. A drug with potent pharmacological activity is converted to a major metabolite with markedly reduced or no pharmacological activity (e.g., Pentobarbital and Hydroxypentobarbital)
2. A drug is converted to a metabolite with roughly equivalent or slightly lower pharmacological activity.

Template:WH Template:WS