Dextro-transposition of the great arteries epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]; Keri Shafer, M.D. [4]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [5]

Overview

Transposition of the great arteries (TGA) is one of the most common cyanotic congenital heart defects present in the first 24 hours of life.

Epidemiology and Demographics

Heart defects are the most common birth defect, occurring in approximately 1% of live births.
Transposition of the great arteries TGA is one of the most common cyanotic congenital heart defects present in the first 24 hours of life.
Approximately one million people worldwide are currently living with a CHD.
TGA represents 5-7% of all CHD with an incidence at birth of 20-30 in 100000 live births and almost 20 percent of all cyanotic CHD defects.
TGA is more common in infants of diabetic mothers.
Boys outnumber girls with an approximate ratio of 2:1.
Without treatment, 30% of infants die within the first week of life, 50% will die in the first month, 70% will die in the first 6 months and 90% of infants will die before the end of the first year.
Having a child with a CHD increases an individual’s chances of having another child with a CHD from 1% to 3%. Subsequent children born with a CHD increase that individual’s chances further.

References

Overview