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Dicobalt edetate
Introduction
Overview
Overview
Dicobalt edetate is the coordination compound with the approximate formula Co2(EDTA)(H2O)6.
Solutions of this solid have been used in Europe as an antidote to cyanide poisoning.[1]
It is a derivative of the (non-natural) amino acid ethylenediaminetetraacetate.
Structure
Structure
The compound is polymeric in the crystalline form. Half of the Co2+ ions are bound to the EDTA2− and the other Co2+ ions are bound to four water ligands as well as carboxylate ligands on the [Co(EDTA)]2− entity.[2] In aqueous solution, depolymerization occurs to give [Co(EDTA)]2− and [Co(H2O)6]2+ ions, each of which is kinetically labile and has a high affinity for cyanide. Oxidants would convert the [Co(EDTA)]2− into [Co(EDTA)]−, which would be unreactive toward cyanide because this complex would be “inert.”[3]
References
References
- ↑ Pickering WG (December 1985). “Cyanide toxicity and the hazards of dicobalt edetate”. Br Med J (Clin Res Ed). 291 (6509): 1644. doi:10.1136/bmj.291.6509.1644-a. PMC 1418389. PMID 2866807.
- ↑ E. F. K. Mccandlish, T. K. Michael; Rose, N. J.; Neal, J. A.; Lingafelter, E. C.; Rose, N. J. (1978). “Comparison of the Structures and Aqueous Solutions of [(O-Phenylenediaminetetraacetato(2-)]Cobalt(II) and [Ethylenediaminetetraacetato(2-)]Cobalt(II)”. Inorg. Chem. 17 (6): 1383–94. doi:10.1021/ic50184a001.
- ↑ Dwyer, F. P.; Garvan, F. L.; Kirschner, Stanley (1960). “Resolution of the Ethylenediaminetetracetatocobaltate(III) Ion”. Inorg. Synth. Inorganic Syntheses. 4: 192–4. doi:10.1002/9780470132371.ch61. ISBN 978-0-470-13237-1.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]