Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Diiodotyrosine
Introduction
Overview
Overview
Diiodotyrosine (DIT) is a precursor in the production of thyroid hormone, and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.
Function
Function
DIT is a modulator of the enzyme thyroid peroxidase (which is involved in the production of thyroid hormones).[1]
Triiodothyronine is formed, when diiodotyrosine is combined with monoiodotyrosine (in the colloid of the thyroid follicle).
Two molecules of DIT combine to make the thyroid hormone thyroxine (‘T4’ and ‘T3’).
References
References
- ↑ Dème D, Fimiani E, Pommier J, Nunez J (February 1975). “Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase”. Eur. J. Biochem. 51 (2): 329–36. doi:10.1111/j.1432-1033.1975.tb03932.x. PMID 1149735.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]