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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Dishevelled

Introduction


Dishevelled (Dsh) is a family of proteins involved in non-canonical Wnt signalling pathways. Dsh is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors.[1]

Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation and cell polarity to social behavior.[2]

Members

Members

There are three human genes that encode dishevelled proteins:[3]

References

References

  1. ↑ Penton A, Wodarz A, Nusse R (2002). “A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin”. Genetics. 161 (2): 747–62. PMC 1462152. PMID 12072470. Unknown parameter |month= ignored (help)
  2. ↑ Wallingford JB, Habas R (2005). “The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity”. Development. 132 (20): 4421–36. doi:10.1242/dev.02068. PMID 16192308. Unknown parameter |month= ignored (help)
  3. ↑ Lee YN, Gao Y, Wang HY (2008). “Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3”. Cell. Signal. 20 (2): 443–52. doi:10.1016/j.cellsig.2007.11.005. PMID 18093802. Unknown parameter |month= ignored (help)
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