Disseminated intravascular coagulation diagnostic study of choice

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[3]

Overview

There is no single diagnostic study of choice for DIC, though DIC may be diagnosed based on the diagnostic criteria established by Japanese Society on Thrombosis and Hemostasis.

Diagnostic Study of Choice

Study of choice

There is no single diagnostic study of choice for the diagnosis of disseminated intravascular coagulation. DIC is a clinical as well as a laboratory diagnosis.

Name of Diagnostic Criteria

There is no single diagnostic study of choice for DIC, though DIC may be diagnosed based on the diagnostic criteria established by Japanese Society on Thrombosis and Hemostasis.^[1]

JSTH’s DIC diagnostic criteria^[1]

	Classification of type	Basic		Hematopoietic disorder		Infectious
Global coagulation tests	Platelet count (×10³/μl)	>120	0 p			>120	0 p
		80 < − ≤ 120	1 p			80 < − ≤ 120	1 p
		50 < − ≤ 80	2 p			50 < − ≤ 80	2 p
		≤50	3 p			≤50	3 p
		≥30% decrease w/in 24 h (*1)	+1 p			≥30% decrease w/in 24 h (*1)	+1 p
	FDP (μg/ml)	<10	0 p	<10	0 p	<10	0 p
		10 ≤ − < 20	1 p	10 ≤ − < 20	1 p	10 ≤ − < 20	1 p
		20 ≤ − < 40	2 p	20 ≤ − < 40	2 p	20 ≤ − < 40	2 p
		≥40	3 p	≥40	3 p	≥40	3 p
	Fibrinogen (mg/dl)	>150	0 p	>150	0 p
		100 < − ≤ 150	1 p	100 < − ≤ 150	1 p
		≤100	2 p	≤100	2 p
	Prothrombin time ratio	<1.25	0 p	<1.25	0 p	<1.25	0 p
		1.25 ≤ − < 1.67	1 p	1.25 ≤ − < 1.67	1 p	1.25 ≤ − < 1.67	1 p
		≥1.67	2 p	≥1.67	2 p	≥1.67	2 p
Hemostatic molecular markers	Antithrombin (%)	>70	0 p	>70	0 p	>70	0 p
	Antithrombin (%)	≤70	1 p	≤70	1 p	≤70	1 p
	TAT, SF or F₁₊₂	<2-fold of normal upper limit	0 p	<2-fold of normal upper limit	0 p	<2-fold of normal upper limit	0 p
	TAT, SF or F₁₊₂	≥2-fold of normal upper limit	1 p	≥2-fold of normal upper limit	1 p	≥2-fold of normal upper limit	1 p
Liver failure (*2)		No	0 p	No	0 p	No	0 p
Liver failure (*2)		Yes	−3 p	Yes	−3 p	Yes	−3 p
DIC diagnosis		≥6 p		≥4 p		≥5 p

References

↑ ^1.0 ^1.1 Wada H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, Madoiwa S, Asakura H (2017). “The approval of revised diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis”. Thromb J. 15: 17. doi:10.1186/s12959-017-0142-4. PMC 5496332. PMID 28680365.

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[pmid28680365-1] 1.0 ^1.1 Wada H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, Madoiwa S, Asakura H (2017). “The approval of revised diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis”. Thromb J. 15: 17. doi:10.1186/s12959-017-0142-4. PMC 5496332. PMID 28680365.

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