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Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Disseminated intravascular coagulation diagnostic study of choice

Introduction

Overview

Overview

There is no single diagnostic study of choice for DIC, though DIC may be diagnosed based on the diagnostic criteria established by Japanese Society on Thrombosis and Hemostasis.

Diagnostic Study of Choice

Diagnostic Study of Choice

Study of choice

There is no single diagnostic study of choice for the diagnosis of disseminated intravascular coagulation. DIC is a clinical as well as a laboratory diagnosis.

Name of Diagnostic Criteria

There is no single diagnostic study of choice for DIC, though DIC may be diagnosed based on the diagnostic criteria established by Japanese Society on Thrombosis and Hemostasis.[1]

JSTH’s DIC diagnostic criteria[1]

Classification of type Basic Hematopoietic disorder Infectious
Global coagulation tests Platelet count (Γ—103/ΞΌl) >120 0 p >120 0 p
80 < βˆ’ ≀ 120 1 p 80 < βˆ’ ≀ 120 1 p
50 < βˆ’ ≀ 80 2 p 50 < βˆ’ ≀ 80 2 p
≀50 3 p ≀50 3 p
β‰₯30% decrease w/in 24 h (*1) +1 p β‰₯30% decrease w/in 24 h (*1) +1 p
FDP

(ΞΌg/ml)

<10 0 p <10 0 p <10 0 p
10 ≀ βˆ’ < 20 1 p 10 ≀ βˆ’ < 20 1 p 10 ≀ βˆ’ < 20 1 p
20 ≀ βˆ’ < 40 2 p 20 ≀ βˆ’ < 40 2 p 20 ≀ βˆ’ < 40 2 p
β‰₯40 3 p β‰₯40 3 p β‰₯40 3 p
Fibrinogen

(mg/dl)

>150 0 p >150 0 p
100 < βˆ’ ≀ 150 1 p 100 < βˆ’ ≀ 150 1 p
≀100 2 p ≀100 2 p
Prothrombin time ratio <1.25 0 p <1.25 0 p <1.25 0 p
1.25 ≀ βˆ’ < 1.67 1 p 1.25 ≀ βˆ’ < 1.67 1 p 1.25 ≀ βˆ’ < 1.67 1 p
β‰₯1.67 2 p β‰₯1.67 2 p β‰₯1.67 2 p
Hemostatic molecular markers Antithrombin

(%)

>70 0 p >70 0 p >70 0 p
≀70 1 p ≀70 1 p ≀70 1 p
TAT, SF or F1+2 <2-fold of normal upper limit 0 p <2-fold of normal upper limit 0 p <2-fold of normal upper limit 0 p
β‰₯2-fold of normal upper limit 1 p β‰₯2-fold of normal upper limit 1 p β‰₯2-fold of normal upper limit 1 p
Liver failure

(*2)

No 0 p No 0 p No 0 p
Yes βˆ’3 p Yes βˆ’3 p Yes βˆ’3 p
DIC diagnosis β‰₯6 p β‰₯4 p β‰₯5 p
References

References

  1. ↑ 1.0 1.1 Wada H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, Madoiwa S, Asakura H (2017). “The approval of revised diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis”. Thromb J. 15: 17. doi:10.1186/s12959-017-0142-4. PMCΒ 5496332. PMIDΒ 28680365.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[3]