Donovanosis history and symptoms

Patients develop the following local symptoms, typically 3 to 40 days after sexual contact: painless papules, painless ulcers of granulomatous tissue that spread and bleed easily, periadenitis, “pseudobuboes”, and absent lymphadenopathy. If the disease disseminates as a result of chronic ulcers, systemic symptoms may develop including: fever, malaise, anemia, night sweats, weight loss and toxemia.

Patients who present to a physician will typically report sexual contact from 3 to 40 days prior to symptom onset.^[1]

Local symptoms include:^[2][3]

• Painless papule(s)
• Painless Ulcer(s) of granulomatous tissue
• Ulcers spreading and wearing away skin
• Ulcer bleeding
• Periadenitis
• “Psuedobuboes”: firm nodules or abscesses
• Absent lymphadenopathy

If the disease disseminates as a result of chronic ulcers, systemic symptoms may develop including:^[2]

• Fever
• Malaise
• Anemia
• Toxemia
• Night sweats
• Weight loss

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