Health Dictionary
Reliable, easy-to-read patient information on common medical conditions ā written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Dopexamine
Introduction
Overview
Overview
Dopexamine is a synthetic analogue of dopamine. Despite this, it is a Ī²1 and Ī²2-adrenergic receptor agonist.[1] Its action at dopamine receptor D1 mediates relaxation of vascular smooth muscle in renal, mesenteric, cerebral and coronary arteries. Mild action at D2 receptors decreases noradrenaline release.[2]
Use in sepsis has been proposed.[3]
It is used as an inotropic agent in cardiac failure.[4] Side effects include arrhythmia, tremor, angina and flushing.
References
References
- ā Perrin G, Papazian L, Martin C. (1993). “Dopexamine: a new dopaminergic agonist”. Ann Fr Anesth Reanim. 12 (3): 308ā320. PMIDĀ 7902685.
- ā Brown RA, Dixon J, Farmer JB; et al. (July 1985). “Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors”. Br. J. Pharmacol. 85 (3): 599ā608. doi:10.1111/j.1476-5381.1985.tb10554.x. PMCĀ 1916510. PMIDĀ 2862944.
- ā Birnbaum J, Klotz E, Spies CD; et al. (2006). “Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats”. Crit Care. 10 (4): R117. doi:10.1186/cc5011. PMCĀ 1750974. PMIDĀ 16893450.
- ā Lisbon A (May 2003). “Dopexamine, dobutamine, and dopamine increase splanchnic blood flow: what is the evidence?”. Chest. 123 (5 Suppl): 460Sā3S. doi:10.1378/chest.123.5_suppl.460S. PMIDĀ 12740229.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]