Dopexamine
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Overview
Dopexamine is a synthetic analogue of dopamine. Despite this, it is a β1 and β2-adrenergic receptor agonist.[1] Its action at dopamine receptor D1 mediates relaxation of vascular smooth muscle in renal, mesenteric, cerebral and coronary arteries. Mild action at D2 receptors decreases noradrenaline release.[2]
Use in sepsis has been proposed.[3]
It is used as an inotropic agent in cardiac failure.[4] Side effects include arrhythmia, tremor, angina and flushing.
References
References
- ↑ Perrin G, Papazian L, Martin C. (1993). “Dopexamine: a new dopaminergic agonist”. Ann Fr Anesth Reanim. 12 (3): 308–320. PMID 7902685.
- ↑ Brown RA, Dixon J, Farmer JB; et al. (July 1985). “Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors”. Br. J. Pharmacol. 85 (3): 599–608. doi:10.1111/j.1476-5381.1985.tb10554.x. PMC 1916510. PMID 2862944.
- ↑ Birnbaum J, Klotz E, Spies CD; et al. (2006). “Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats”. Crit Care. 10 (4): R117. doi:10.1186/cc5011. PMC 1750974. PMID 16893450.
- ↑ Lisbon A (May 2003). “Dopexamine, dobutamine, and dopamine increase splanchnic blood flow: what is the evidence?”. Chest. 123 (5 Suppl): 460S–3S. doi:10.1378/chest.123.5_suppl.460S. PMID 12740229.
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