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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Duodenal atresia pathophysiology

Introduction

Overview

Overview

It is thought that duodenal atresia is the result of failure of neural cell migration during the 8th to 10th week of duodenal re-canalization. It is associated with down syndrome, vertebral defects, anal anomalies, esophageal atresia, annular pancreas, malrotation, renal abnormalities, cardiac causes, and mandibulofacial anomalies.

Pathophysiology

Pathophysiology

Pathogenesis

  • Duodenum starts developing during the 6th and 7th week of gestation.[1][2]
    • Re-canalization occurs during the 8th to 10th week of gestation.
  • It is thought that duodenal atresia is the result of failure of re-canalization of the duodenum in 8 to 10 weeks of fetal development.
    • This is due to failure of neural cell migration
Duodenum Anatomy.Source: Libre Pathology
Genetics

Genetics

Associated Conditions

Associated Conditions

Duodenal atresia is commonly associated with the following:[3][4]

References

References

  1. ↑ Ando H, Kaneko K, Ito F, Seo T, Harada T, Watanabe Y (1999). “Embryogenesis of pancreaticobiliary maljunction inferred from development of duodenal atresia”. J Hepatobiliary Pancreat Surg. 6 (1): 50–4. PMID 10436237.
  2. ↑ Boyden EA, Cope JG, Bill AH (1967). “Anatomy and embryology of congenital intrinsic obstruction of the duodenum”. Am J Surg. 114 (2): 190–202. PMID 6028984.
  3. ↑ Freeman, SB; Torfs, CP; Romitti, PA; Royle, MH; Druschel, C; Hobbs, CA; Sherman, SL (2009). “Congenital gastrointestinal defects in Down syndrome: a report from the Atlanta and National Down Syndrome Projects”. Clinical Genetics. 75 (2): 180–184. doi:10.1111/j.1399-0004.2008.01110.x. ISSN 0009-9163.
  4. ↑ Morris, Grant; Kennedy, Alfred; Cochran, William (2016). “Small Bowel Congenital Anomalies: a Review and Update”. Current Gastroenterology Reports. 18 (4). doi:10.1007/s11894-016-0490-4. ISSN 1522-8037.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]