Health Dictionary
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EFNB3
Introduction
Ephrin-B3, also known as EFNB3, is a human gene.[1]
EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.[1]
Further reading
Further reading
- Flanagan JG, Vanderhaeghen P (1998). “The ephrins and Eph receptors in neural development”. Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
- Zhou R (1998). “The Eph family receptors and ligands”. Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
- Holder N, Klein R (1999). “Eph receptors and ephrins: effectors of morphogenesis”. Development. 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). “Eph receptors and ephrins: regulators of guidance and assembly”. Int. Rev. Cytol. 196: 177–244. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). “Roles of Eph receptors and ephrins in segmental patterning”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
- Wilkinson DG (2001). “Multiple roles of EPH receptors and ephrins in neural development”. Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
- Gale NW, Flenniken A, Compton DC; et al. (1996). “Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments”. Oncogene. 13 (6): 1343–52. PMID 8808709.
- Tang XX, Pleasure DE, Ikegaki N (1997). “cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors”. Genomics. 41 (1): 17–24. doi:10.1006/geno.1997.4615. PMID 9126477.
- “Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee”. Cell. 90 (3): 403–4. 1997. PMID 9267020.
- Bergemann AD, Zhang L, Chiang MK; et al. (1998). “Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube”. Oncogene. 16 (4): 471–80. doi:10.1038/sj.onc.1201557. PMID 9484836.
- Brückner K, Pablo Labrador J, Scheiffele P; et al. (1999). “EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains”. Neuron. 22 (3): 511–24. PMID 10197531.
- Liu W, Ahmad SA, Jung YD; et al. (2002). “Coexpression of ephrin-Bs and their receptors in colon carcinoma”. Cancer. 94 (4): 934–9. PMID 11920461.
- Takemoto M, Fukuda T, Sonoda R; et al. (2002). “Ephrin-B3-EphA4 interactions regulate the growth of specific thalamocortical axon populations in vitro”. Eur. J. Neurosci. 16 (6): 1168–72. PMID 12383247.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.