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ELAVL1

Introduction

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R), also known as ELAVL1, is a human gene.

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It stabilizes mRNAs and thereby regulates gene expression.[1]

References

References

  1. ↑ “Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)”.
Further reading

Further reading

  • Nabors LB, Suswam E, Huang Y, Yang X, Johnson MJ, King PH (2003). “Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR”. Cancer Res. 63 (14): 4181–87. PMID 12874024.
  • Abdelmohsen K, Lal A, Kim HH, Gorospe M (2007). “Posttranscriptional orchestration of an anti-apoptotic program by HuR”. Cell Cycle. 6 (11): 1288–92. PMID 17534146.
  • Ma WJ, Cheng S, Campbell C; et al. (1996). “Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein”. J. Biol. Chem. 271 (14): 8144–51. PMID 8626503.
  • Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. PMID 8889548.
  • Ma WJ, Furneaux H (1997). “Localization of the human HuR gene to chromosome 19p13.2”. Hum. Genet. 99 (1): 32–3. PMID 9003489.
  • Sakai K, Kitagawa Y, Hirose G (1999). “Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA”. Biochem. Biophys. Res. Commun. 256 (2): 263–8. doi:10.1006/bbrc.1999.0282. PMID 10079173.
  • Wang W, Furneaux H, Cheng H; et al. (2000). “HuR regulates p21 mRNA stabilization by UV light”. Mol. Cell. Biol. 20 (3): 760–9. PMID 10629032.
  • Blaxall BC, Pellett AC, Wu SC; et al. (2000). “Purification and characterization of beta-adrenergic receptor mRNA-binding proteins”. J. Biol. Chem. 275 (6): 4290–7. PMID 10660597.
  • Park S, Myszka DG, Yu M; et al. (2000). “HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA”. Mol. Cell. Biol. 20 (13): 4765–72. PMID 10848602.
  • SpÃ¥ngberg K, Wiklund L, Schwartz S (2000). “HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3′ ends of hepatitis C virus RNA of both polarities”. Virology. 274 (2): 378–90. doi:10.1006/viro.2000.0461. PMID 10964780.
  • Brennan CM, Gallouzi IE, Steitz JA (2000). “Protein ligands to HuR modulate its interaction with target mRNAs in vivo”. J. Cell Biol. 151 (1): 1–14. PMID 11018049.
  • Gallouzi IE, Brennan CM, Steitz JA (2001). “Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock”. RNA. 7 (9): 1348–61. PMID 11565755.
  • Gallouzi IE, Steitz JA (2001). “Delineation of mRNA export pathways by the use of cell-permeable peptides”. Science. 294 (5548): 1895–901. doi:10.1126/science.1064693. PMID 11729309.
  • Goldberg-Cohen I, Furneauxb H, Levy AP (2002). “A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR”. J. Biol. Chem. 277 (16): 13635–40. doi:10.1074/jbc.M108703200. PMID 11834731.
  • Wang W, Fan J, Yang X; et al. (2002). “AMP-activated kinase regulates cytoplasmic HuR”. Mol. Cell. Biol. 22 (10): 3425–36. PMID 11971974.
  • Yeap BB, Voon DC, Vivian JP; et al. (2002). “Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3′-untranslated region of the androgen receptor messenger RNA”. J. Biol. Chem. 277 (30): 27183–92. doi:10.1074/jbc.M202883200. PMID 12011088.
  • Li H, Park S, Kilburn B; et al. (2003). “Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase”. J. Biol. Chem. 277 (47): 44623–30. doi:10.1074/jbc.M206187200. PMID 12237300.
  • Chen CY, Xu N, Shyu AB (2002). “Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization”. Mol. Cell. Biol. 22 (20): 7268–78. PMID 12242302.
  • Giles KM, Daly JM, Beveridge DJ; et al. (2003). “The 3′-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein”. J. Biol. Chem. 278 (5): 2937–46. doi:10.1074/jbc.M208439200. PMID 12431987.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Wang W, Yang X, López de Silanes I; et al. (2003). “Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function”. J. Biol. Chem. 278 (29): 27016–23. doi:10.1074/jbc.M300318200. PMID 12730239.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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