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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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ENTPD3

Introduction

Ectonucleoside triphosphate diphosphohydrolase 3 is an enzyme that in humans is encoded by the ENTPD3 gene.[1][2]

ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.[2]

References

References

  1. ↑ Chadwick BP, Frischauf AM (Oct 1998). “The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster”. Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
  2. ↑ 2.0 2.1 “Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3”.
Further reading

Further reading

  • Munkonda MN, Kauffenstein G, Kukulski F, et al. (2007). “Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists”. Biochem. Pharmacol. 74 (10): 1524–34. doi:10.1016/j.bcp.2007.07.033. PMID 17727821.
  • Ivanenkov VV, Meller J, Kirley TL (2005). “Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling”. Biochemistry. 44 (25): 8998–9012. doi:10.1021/bi047487z. PMID 15966724.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yang F, Hicks-Berger CA, Smith TM, Kirley TL (2001). “Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions”. Biochemistry. 40 (13): 3943–50. doi:10.1021/bi002711f. PMID 11300774.
  • Smith TM, Lewis Carl SA, Kirley TL (1999). “Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase”. Biochemistry. 38 (18): 5849–57. doi:10.1021/bi990171k. PMID 10231536.
  • Smith TM, Kirley TL (1998). “Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1”. Biochim. Biophys. Acta. 1386 (1): 65–78. doi:10.1016/s0167-4838(98)00063-6. PMID 9675246.
  • Chadwick BP, Frischauf AM (1997). “Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes”. Mamm. Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669.