Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
ERRFI1
Introduction
ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.[1][2][3][4][5]
MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM][5]
References
References
- ↑ 1.0 1.1 Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (Jul 2000). “Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress”. J Biol Chem. 275 (23): 17838–17847. doi:10.1074/jbc.M909735199. PMC 3668664. PMID 10749885.
- ↑ Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK (Oct 1989). “Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity”. Nucleic Acids Res. 17 (16): 6651–6667. doi:10.1093/nar/17.16.6651. PMC 318357. PMID 2780291.
- ↑ Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O (Sep 2002). “Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control”. Oncogene. 21 (42): 6530–6539. doi:10.1038/sj.onc.1205823. PMID 12226756.
- ↑ Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O (Oct 2000). “Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain”. Mol Cell Biol. 20 (20): 7735–7750. doi:10.1128/MCB.20.20.7735-7750.2000. PMC 86354. PMID 11003669.
- ↑ 5.0 5.1 “Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1”.
- ↑ Benzinger, Anne; Muster Nemone; Koch Heike B; Yates John R; Hermeking Heiko (Jun 2005). “Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer”. Mol. Cell. Proteomics. United States. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. ISSN 1535-9476. PMID 15778465.
Further reading
Further reading
- Zhang YW, Vande Woude GF (2007). “Mig-6, signal transduction, stress response and cancer”. Cell Cycle. 6 (5): 507–13. doi:10.4161/cc.6.5.3928. PMID 17351343.
- Wick M, Bürger C, Funk M, Müller R (1995). “Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation”. Exp. Cell Res. 219 (2): 527–535. doi:10.1006/excr.1995.1261. PMID 7641805.
- Hackel PO, Gishizky M, Ullrich A (2002). “Mig-6 is a negative regulator of the epidermal growth factor receptor signal”. Biol. Chem. 382 (12): 1649–1662. doi:10.1515/BC.2001.200. PMID 11843178.
- Tsunoda T, Inokuchi J, Baba I, et al. (2002). “A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6”. Cancer Res. 62 (20): 5668–71. PMID 12384522.
- Saarikoski ST, Rivera SP, Hankinson O (2002). “Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia”. FEBS Lett. 530 (1–3): 186–190. doi:10.1016/S0014-5793(02)03475-0. PMID 12387890.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS…9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Anastasi S, Fiorentino L, Fiorini M, et al. (2003). “Feedback inhibition by RALT controls signal output by the ErbB network”. Oncogene. 22 (27): 4221–4234. doi:10.1038/sj.onc.1206516. PMID 12833145.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Xu D, Makkinje A, Kyriakis JM (2005). “Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function”. J. Biol. Chem. 280 (4): 2924–2933. doi:10.1074/jbc.M408907200. PMID 15556944.
- Keeton AB, Messina JL (2005). “Modulation of Elk-dependent-transcription by Gene33”. J. Cell. Biochem. 94 (6): 1190–1198. doi:10.1002/jcb.20370. PMID 15696545.
- Benzinger A, Muster N, Koch HB, et al. (2005). “Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer”. Mol. Cell. Proteomics. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Anastasi S, Sala G, Huiping C, et al. (2005). “Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin”. Oncogene. 24 (28): 4540–4548. doi:10.1038/sj.onc.1208658. PMID 15856022.
- Ballarò C, Ceccarelli S, Tiveron C, et al. (2006). “Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype”. EMBO Rep. 6 (8): 755–761. doi:10.1038/sj.embor.7400458. PMC 1369136. PMID 16007071.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). “The DNA sequence and biological annotation of human chromosome 1”. Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Zhang YW, Staal B, Su Y, et al. (2007). “Evidence that MIG-6 is a tumor-suppressor gene”. Oncogene. 26 (2): 269–276. doi:10.1038/sj.onc.1209790. PMID 16819504.