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Econazole microbiology
Introduction
| Econazole |
|---|
| ECOZA®,ECONAZOLE NITRATE® FDA Package Insert |
| Description |
| Clinical Pharmacology |
| Microbiology |
| Indications and Usage |
| Contraindications |
| Warnings and Precautions |
| Adverse Reactions |
| Clinical Studies |
| Dosage and Administration |
| Patient Counseling Information |
| How Supplied |
| Labels and Packages |
Microbiology
Microbiology
Mechanism of Action
Econazole nitrate, an azole antifungal agent, inhibits fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylase enzyme. This enzyme functions to convert lanosterol to ergosterol. The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell wall and may be responsible for the fungistatic activity of econazole. Mammalian cell demethylation is less sensitive to econazole inhibition.
Activity in vitro and in clinical infections
Econazole nitrate has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections [seeIndications and Usage (1)].
Trichophyton rubrum Epidermophyton floccosum Trichophyton mentagrophytes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]