Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Eczema causes
Introduction
Overview
Overview
The etiology of eczema is multifactorial and complex. This involves aberrations in genetic components, adverse effects of certain medications, and some environmental factors.
Etiology of Eczema
Etiology of Eczema
Genetic problem
- Damage from the enzymatic activity of allergens is usually prevented by the body’s own protease inhibitors, such as LEKTI, produced from the gene SPINK5.
- Lack of filaggrin gene causes dry skin. [1]
Eczema as an Adverse Drug Reaction
- Eczema can also be brought about by some adverse effects of medications.
- Below is a list of commonly prescribed medications with eczema as the common adverse drug effect (Table 1).
| Medication |
|---|
| Cidofovir |
| Flurbiprofen |
| Olaparib |
| Siltuximab |
| Sorafenib |
| Tiagabine |
References
References
- ↑ Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP; et al. (2006). “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis”. Nat Genet. 38 (4): 441–6. doi:10.1038/ng1767. PMID 16550169.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, DMD, MD[2]