Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Eczema risk factors
Introduction
Risk Factors
Risk Factors
- Hereditary factors
- Genetics is the strongest identifiable factor associated with development of eczema. [1]
- Family history and FLG gene mutation. [2]
- 34 genetic loci have been identified based on genome-wide association studies that accounts for almost 20% of eczema inheritance. [3]
- The profilaggrin protein of the FLG gene maintains the intactness of the skin. [4]
- Peanut allergy, herpes virus, and contact dermatitis were found to be associated with FLG gene mutation.[5] [6]
- Environmental factors
References
References
- ↑ Feld M, Garcia R, Buddenkotte J, Katayama S, Lewis K, Muirhead G; et al. (2016). “The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves”. J Allergy Clin Immunol. 138 (2): 500–508.e24. doi:10.1016/j.jaci.2016.02.020. PMID 27212086.
- ↑ Sicherer SH, Leung DY (2009). “Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2008”. J Allergy Clin Immunol. 123 (2): 319–27. doi:10.1016/j.jaci.2008.12.025. PMID 19203656.
- ↑ Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP; et al. (2015). “Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis”. Nat Genet. 47 (12): 1449–1456. doi:10.1038/ng.3424. PMC 4753676. PMID 26482879.
- ↑ Sandilands A, Sutherland C, Irvine AD, McLean WH (2009). “Filaggrin in the frontline: role in skin barrier function and disease”. J Cell Sci. 122 (Pt 9): 1285–94. doi:10.1242/jcs.033969. PMC 2721001. PMID 19386895.
- ↑ Leung DY, Guttman-Yassky E (2014). “Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches”. J Allergy Clin Immunol. 134 (4): 769–79. doi:10.1016/j.jaci.2014.08.008. PMC 4186710. PMID 25282559.
- ↑ Irvine AD, McLean WH, Leung DY (2011). “Filaggrin mutations associated with skin and allergic diseases”. N Engl J Med. 365 (14): 1315–27. doi:10.1056/NEJMra1011040. PMID 21991953.
- ↑ Silverberg JI, Hanifin J, Simpson EL (2013). “Climatic factors are associated with childhood eczema prevalence in the United States”. J Invest Dermatol. 133 (7): 1752–9. doi:10.1038/jid.2013.19. PMC 3646081. PMID 23334343.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.