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Enadoline

Introduction

Enadoline is a drug which acts as a highly selective Îș-opioid agonist.

In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of Salvinorin-A.[1]

It was looked at as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a Îș-opioid agonist. There was mention of its potential in treating comatose head injury or stroke victims, where that type of side effect would be immaterial.[2]

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See also

See also

References

References

  1. ↑ Walsh SL, Strain EC, Abreu ME, Bigelow GE (2001). “Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans”. Psychopharmacology (Berl.). 157 (2): 151–62. PMID 11594439.
  2. ↑ Barber A, Gottschlich R (1997). “Novel developments with selective, non-peptidic kappa-opioid receptor agonists”. Expert Opin Investig Drugs. 6 (10): 1351–68. doi:10.1517/13543784.6.10.1351. PMID 15989506.

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