
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions â written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Enadoline
Introduction
Enadoline is a drug which acts as a highly selective Îș-opioid agonist.
In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of Salvinorin-A.[1]
It was looked at as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a Îș-opioid agonist. There was mention of its potential in treating comatose head injury or stroke victims, where that type of side effect would be immaterial.[2]
References
References
- â Walsh SL, Strain EC, Abreu ME, Bigelow GE (2001). “Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans”. Psychopharmacology (Berl.). 157 (2): 151â62. PMIDÂ 11594439.
- â Barber A, Gottschlich R (1997). “Novel developments with selective, non-peptidic kappa-opioid receptor agonists”. Expert Opin Investig Drugs. 6 (10): 1351â68. doi:10.1517/13543784.6.10.1351. PMIDÂ 15989506.
Template:Dissociative hallucinogens Template:WikiDoc Sources
