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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Endothelial lipase

Introduction

Endothelial lipase is a form of lipase secreted by vascular endothelial cells in tissues with high metabolic rates and vascularization, such as the liver, lung, kidney, and thyroid gland.[1] Unlike the lipases that hydrolyze triglycerides, endothelial lipase primarily hydrolyzes phospholipids.[1]

It was first characterized in 1999.[2]

References

References

  1. ↑ 1.0 1.1 Yu JE, Han SY, Wolfson B, Zhou Q (2018). “The role of endothelial lipase in lipid metabolism, inflammation, and cancer”. Histology and Histopathology. 33 (1): 1–10. doi:10.14670/HH-11-905. PMC 5858721. PMID 28540715.
  2. ↑ Jaye M, Lynch KJ, Krawiec J, et al. (1999). “A novel endothelial-derived lipase that modulates HDL metabolism”. Nat. Genet. 21 (4): 424–8. doi:10.1038/7766. PMID 10192396.
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