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Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Enteropathy-associated T-cell lymphoma natural history, complications and prognosis

Introduction

Overview

Overview

Enteropathy-associated T-cell lymphoma is usually a fast-growing (aggressive) lymphoma. Common complications of enteropathy-associated T-cell lymphoma include ulcer, obstruction, and perforation of small intestine. Prognosis is generally poor.

Natural History

Natural History

  • Enteropathy-associated T-cell lymphoma is usually a fast-growing (aggressive) lymphoma.[1]
  • It is associated with celiac disease (sprue).
  • Most adults are diagnosed with celiac disease at the same time as their lymphoma or shortly before their lymphoma is diagnosed.
  • Enteropathy-associated T-cell lymphoma may spread to the liver, spleen, lymph nodes, gallbladder, stomach, colon or skin.
Complications

Complications

  • Common complications of enteropathy-associated T-cell lymphoma include:[1][2]
Prognosis

Prognosis

  • The prognosis for people with enteropathy-associated T-cell lymphoma is often not very good.[1][3]
  • Recurrences most frequent in the small intestine.[4]
  • The most influential prognostic factor is bulky nature of disease, defined by a tumor mass greater than 5 cm. [5] [6]
  • Autologous stem cell transplantation is a useful way of treatment for selected patients with enteropathy-associated T-cell lymphoma and can control disease progress.
References

References

  1. ↑ 1.0 1.1 1.2 Enteropathy-associated T-cell lymphoma . Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/enteropathy-associated-t-cell-lymphoma/?region=on Accessed on January 27, 2016
  2. ↑ Kabul S, Uğraş N, Yerci Γ–, Γ–ztΓΌrk E (2018). “Perforation of the small intestine caused by enteropathy-associated T cell lymphoma”. Turk J Surg. 34 (3): 253–255. doi:10.5152/turkjsurg.2017.3278. PMCΒ 6173604. PMIDΒ 30302434.
  3. ↑ Nijeboer P, de Baaij LR, Visser O, Witte BI, Cillessen SA, Mulder CJ, Bouma G (June 2015). “Treatment response in enteropathy associated T-cell lymphoma; survival in a large multicenter cohort”. Am. J. Hematol. 90 (6): 493–8. doi:10.1002/ajh.23992. PMIDΒ 25716069.
  4. ↑ Enteropathy-associated T-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd5315/. Accessed on January 27, 2016
  5. ↑ Delabie J, et al. (July 2011). “Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project”. Blood. 118 (148): 148. doi:10.1182/blood-2011-02-335216.
  6. ↑ Kumar, A.; Burger, I. A.; Zhang, Z.; Drill, E. N.; Migliacci, J. C.; Ng, A.; LaCasce, A.; Wall, D.; Witzig, T. E.; Ristow, K.; Yahalom, J.; Moskowitz, C. H.; Zelenetz, A. D. (2016). “Definition of bulky disease in early stage Hodgkin lymphoma in computed tomography era: prognostic significance of measurements in the coronal and transverse planes”. Haematologica. 101 (10): 1237–1243. doi:10.3324/haematol.2016.141846. ISSNΒ 0390-6078.


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]