Common risk factors in the development of esophagitis are immunosuppression, alcohol use, smoking, excessive vomiting, certain medications, and surgery or radiation to the chest.

Common risk factors in the development of EoE include:^{[1][2][3][4][5][6]}

• Age- EoE has a bimodal age distribution common in both children and adults.
• Sex- Males are more prone to EoE than the females.
• Weather- Cold and dry climate trigger EoE.
• Location- EoE is common in people with a history of European ancestry.
• Season- Summer and fall, this is because people stay outdoors during this time and the higher levels of the pollen and the other allergens during these seasons.
• Family history- EoE runs in the family and it is more common in people with a positive family history of the EoE.
• History of allergies- EoE is very common in patient with a history of allergies such as asthma, industrial exposures, environmental allergies, chronic respiratory disease, food allergies and atopic dermatitis.

Common risk factors in the development of reflux esophagitis include:

• Smoking
• Obesity
• Pregnancy
• Hiatal hernia
• Scleroderma
• Alcohol consumption
• Consuming drinks that contain caffeine

• Medications:

• Anticholinergics (e.g. for seasickness)
• Beta blockers for high blood pressure or heart disease
• Bronchodilators for asthma
• Calcium channel blockers for high blood pressure
• Dopamine-active drugs for Parkinson’s disease
• Progestin for abnormal menstrual bleeding or birth control
• Sedatives for insomnia or anxiety
• Tricyclic antidepressants