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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Essential thrombocytosis surgery

Introduction

Overview

Overview

Surgical intervention is not recommended for the management of essential thrombocytosis.

Perioperative management should have a multidisciplinary approach involving hematology and the surgical team.

Some experts target preprocedure platelet counts <450 x 10^9/L in high-risk and <600 x 10^9/L in low-risk patients.[1] Achieving the low-risk target may require a short course of hydroxyurea. Evidence is lacking for perioperative aspirin/anticoagulation decisions specific to ET, so experts recommend following general perioperative guidelines for people without ET.

Surgery

Surgery

Surgical intervention is not recommended for the management of essential thrombocytosis.

Perioperative management should have a multidisciplinary approach involving hematology and the surgical team.

Some experts target preprocedure platelet counts <450 x 10^9/L in high-risk and <600 x 10^9/L in low-risk patients.[2] Achieving the low-risk target may require a short course of hydroxyurea.

Evidence is lacking for perioperative aspirin/anticoagulation decisions specific to ET, so experts recommend following general perioperative guidelines for people without ET.

In a retrospective review of 66 patients undergoing 121 procedures,[3] there was no perioperative bleeding; 90-day postoperative risks were 1% arterial thrombosis, 1% venous thrombosis, 4% hemorrhage, and 2% death. Findings suggest continuing cytoreductive and aspirin therapy may be reasonable for most surgeries unless the procedure has high bleeding risk.

References

References

  1. ↑ Tefferi A, Gangat N, Loscocco GG, Guglielmelli P, Szuber N, Pardanani A, Orazi A, Barbui T, Vannucchi AM (February 2025). “Essential Thrombocythemia: A Review”. JAMA. 333 (8): 701–714. doi:10.1001/jama.2024.25349. PMID 39869325 Check |pmid= value (help).
  2. ↑ Tefferi A, Gangat N, Loscocco GG, Guglielmelli P, Szuber N, Pardanani A, Orazi A, Barbui T, Vannucchi AM (February 2025). “Essential Thrombocythemia: A Review”. JAMA. 333 (8): 701–714. doi:10.1001/jama.2024.25349. PMID 39869325 Check |pmid= value (help).
  3. ↑ Tefferi A, Gangat N, Loscocco GG, Guglielmelli P, Szuber N, Pardanani A, Orazi A, Barbui T, Vannucchi AM (February 2025). “Essential Thrombocythemia: A Review”. JAMA. 333 (8): 701–714. doi:10.1001/jama.2024.25349. PMID 39869325 Check |pmid= value (help).


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]Parth Vikram Singh, MBBS[3]