Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Esthesioneuroblastoma classification
Introduction
Overview
Overview
Based on the duration of symptoms, esthesioneuroblastoma may be classified into two subtypes: neuroblastoma proper and neuroendocrine carcinomas.[1]
Classification
Classification
- Neuroblastoma proper
- Neuroblastoma proper has a histologic presentation similar to that of peripheral neuroblastomas of childhood.
- Esthesioneuroblastoma is composed of sheets of poorly demarcated groups of cells separated by fine connective tissue trabeculae.
- The cells are small and typically show no mitotic activity between the cells.
- Rosettes of the Homer-Wright type are present.
- On electronic microscopy, there is the presence of a dendritic cytoplasmic process with accumulations of small core granules within the process.
- Neuroblastomas proper contain fibrillary material.
- Neuroendocrine carcinomas
- Neuroendocrine carcinoma is admixture with glands.
- A neurofibrillary component is absent and the growth pattern is that of solid nests without rosettes.
- Dense core granules similar to those of neuroblastomas are present in the cytoplasm and cytoplasmic extensions.
References
References
- ↑ Min KW (1995). “Usefulness of electron microscopy in the diagnosis of “small” round cell tumors of the sinonasal region”. Ultrastruct Pathol. 19 (5): 347–63. PMID 7483011.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]