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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Etazolate

Introduction

Overview

Overview

Etazolate is a pyrazolopyridine derivative drug,[1] which acts as an anxiolytic.[2]

It has several mechanisms of action, acting as an adenosine antagonist,[3] a subtype-selective GABAA receptor partial agonist,[4] and a phosphodiesterase inhibitor selective for the PDE4 subtype.[5]

See also

See also

References

References

  1. ↑ Ticku MK, Davis WC (1982). “Molecular interactions of etazolate with benzodiazepine and picrotoxinin binding sites”. J. Neurochem. 38 (4): 1180–2. PMID 6278085.
  2. ↑ Williams M. Anxioselective anxiolytics. Journal of Medicinal Chemistry. 1983 May;26(5):619-28. PMID 6132997
  3. ↑ Williams M, Jarvis MF. Adenosine antagonists as potential therapeutic agents. Pharmacology Biochemistry and Behaviour. 1988 Feb;29(2):433-41. PMID 3283781
  4. ↑ Zezula J, Slany A, Sieghart W. Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. European Journal of Pharmacology. 1996 Apr 22;301(1-3):207-14. PMID 8773466
  5. ↑ Wang P, Myers JG, Wu P, Cheewatrakoolpong B, Egan RW, Billah MM. Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. Biochemical and Biophysical Research Communications. 1997 May 19;234(2):320-4. PMID 9177268

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]