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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Euthyroid sick syndrome causes

Introduction

Overview

Overview

Euthyroid sick syndrome can be caused by any serious illness which leads to increased level of cytokines, decreased level of leptin, hyper-metabolism, decreased protein synthesis and decreased level of thyroid-binding globulin. The conditions include sepsis, malignancy, trauma, surgery, burns, bone marrow transplantation, metabolic disorders, and other inflammatory conditions.

Causes

Causes

Common Causes

Euthyroid sick syndrome can be caused by any serious illness which leads to increased level of cytokines, decreased level of leptin, hyper-metabolism, iodine containing contrast medium, decreased protein synthesis and decreased level of thyroxin-binding globulin. The conditions include:[1][2][3]

Less Common Causes

  • The following table summarize the effect of various drugs on thyroid hormones level:
↓ Hormone secretion ↓ T4 ↓ TSH ↓ 5′ monodeiodinase ↑ Breakdown of

thyroid hormones

Thyroid binding globulin
Increased Decreased
References

References

  1. ↑ Silva MH, Araujo MC, Diniz EM, Ceccon ME, Carvalho WB (2015). “Nonthyroidal illnesses syndrome in full-term newborns with sepsis”. Arch Endocrinol Metab. 59 (6): 528–34. doi:10.1590/2359-3997000000111. PMID 26677087.
  2. ↑ FrÄ…czek MM, Gackowski A, Przybylik-Mazurek E, Nessler J (2016). “[The relation between the low T3 syndrome in the clinical course of myocardial infarction and heart failure]”. Pol. Merkur. Lekarski (in Polish). 40 (240): 380–3. PMID 27403906.
  3. ↑ Girvent M, Maestro S, Hernández R, Carajol I, Monné J, Sancho JJ, Gubern JM, Sitges-Serra A (1998). “Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation”. Surgery. 123 (5): 560–7. doi:10.1067/msy.1998.87238. PMID 9591009.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]