Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Extranodal NK-T-cell lymphoma epidemiology and demographics
Introduction
Overview
Overview
NK cell lymphoma shows a poor prognosis because of rapid local progression and distant metastasis.The median age of onset is approximately 50 years and it is common in elderly. extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensitivity or other EBV-associated disease.Natural Killer (NK) cell lymphoma is a rare disease. extranodal NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of non-Hodgkin lymphoma in Asia and South America and less than 1000 in 10000 patient in western countries
Epidemiology and Demographics
Epidemiology and Demographics
Mortality rate
- NK cell lymphoma shows a poor prognosis because of rapid local progression and distant metastasis.[1]
Age
- The median age of onset is approximately 50 years and it is common in the elderly.
- Extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensitivity or other EBV-associated disease.[2]
Race
- Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.
- Nk cell lymphoma is usually associated with Epstein-Barr virus infection.[3]
Gender
- Extranodal NK/T-cell lymphoma shows male preponderance.[4]
Region
- Extranodal NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of non-Hodgkin lymphoma in Asia and South America and less than 1000 in 10000 patient in western countries.
- It is estimated the incidence of NNKTL is higher in Asia by 10-folds.[5]
References
References
- ↑ Jaffe, Elaine S; Nicolae, Alina; Pittaluga, Stefania (2013). “Peripheral T-cell and NK-cell lymphomas in the WHO classification: pearls and pitfalls”. Modern Pathology. 26 (S1): S71–S87. doi:10.1038/modpathol.2012.181. ISSN 0893-3952.
- ↑ Harabuchi, Yasuaki; Takahara, Miki; Kishibe, Kan; Nagato, Toshihiro; Kumai, Takumi (2019). “Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: Basic Science and Clinical Progress”. Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00141. ISSN 2296-2360.
- ↑ Lima, Margarida (2013). “Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis”. Orphanet Journal of Rare Diseases. 8 (1): 95. doi:10.1186/1750-1172-8-95. ISSN 1750-1172.
- ↑ Wang, Xiaotian; Gong, Zimu; Li, Shawn Xiang; Yan, Wei; Song, Yongsheng (2017). “Extranodal nasal-type natural killer/T-cell lymphoma with penile involvement: a case report and review of the literature”. BMC Urology. 17 (1). doi:10.1186/s12894-017-0273-8. ISSN 1471-2490.
- ↑ Haverkos, Bradley M.; Pan, Zenggang; Gru, Alejandro A.; Freud, Aharon G.; Rabinovitch, Rachel; Xu-Welliver, Meng; Otto, Brad; Barrionuevo, Carlos; Baiocchi, Robert A.; Rochford, Rosemary; Porcu, Pierluigi (2016). “Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases”. Current Hematologic Malignancy Reports. 11 (6): 514–527. doi:10.1007/s11899-016-0355-9. ISSN 1558-8211.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]