Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
F-box protein
Introduction
F-box proteins are proteins containing at least one F-box motif, a protein structural motif of about 50 amino acids that mediates protein-protein interactions. The first identified F-box protein is one of three components of the SCF complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome. F-box motifs commonly exist in proteins in concert with other protein-protein interaction motifs such as leucine-rich repeats and WD repeats.[1]
F-box proteins have also been associated with cellular functions such as signal transduction and regulation of the cell cycle.[2] In plants, many F-box proteins are represented in gene networks broadly regulated by microRNA-mediated gene silencing via RNA interference.[3]
References
References
- ↑ Kipreos ET, Pagano M. (2000). The F-box protein family. Genome Biol 1(5):REVIEWS3002. PMID 11178263
- ↑ Craig KL, Tyers M. (1999). The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. Prog Biophys Mol Biol 72(3):299-328. PMID 10581972
- ↑ Jones-Rhoades M, Bartel D, Bartel B. “MicroRNAS and their regulatory roles in plants”. Annu Rev Plant Biol 57: 19-53. PMID 16669754
External links
External links
- F-Box+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)