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Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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FAM3C

Introduction

Protein FAM3C is a protein that in humans is encoded by the FAM3C gene.[1][2]

Function

Function

This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. Alternate transcriptional splice variants which encode the same protein have been characterized.[2] FAM3C functions and expression also were studied in mammalian brains[3][4] which shown that a reduced FAM3C level associated to the onset of sporadic Alzheimer’s disease (AD), which highlighted FAM3C as a promising therapeutic target for Alzheimer’s disease. Moreover, level of FAM3C was claimed to be a biomarker for AD together with saponin D.[5]

References

References

  1. ↑ Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR (August 2002). “Cloning, expression, and initial characterization of a novel cytokine-like gene family”. Genomics. 80 (2): 144–50. doi:10.1006/geno.2002.6816. PMIDΒ 12160727.
  2. ↑ 2.0 2.1 “Entrez Gene: FAM3C family with sequence similarity 3, member C”.
  3. ↑ Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M (June 2014). “The FAM3 superfamily member ILEI ameliorates Alzheimer’s disease-like pathology by destabilizing the penultimate amyloid-Ξ² precursor”. Nature Communications. 5: 3917. doi:10.1038/ncomms4917. PMIDΒ 24894631.
  4. ↑ Liu L, Watanabe N, Akatsu H, Nishimura M (August 2016). “Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer’s disease”. Neuroscience. 330: 236–46. doi:10.1016/j.neuroscience.2016.05.050. PMIDΒ 27256505.
  5. ↑ [1], Davies, Huw Alun; Kaj Blennow & James Norton McGuire, “Saposin D and FAM3C are biomarkers for alzheimer’s disease”Β 
Further reading

Further reading

  • “Toward a complete human genome sequence”. Genome Research. 8 (11): 1097–108. November 1998. doi:10.1101/gr.8.11.1097. PMIDΒ 9847074.
  • Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM (July 2004). “Lineage-specific gene duplication and loss in human and great ape evolution”. PLoS Biology. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMCΒ 449870. PMIDΒ 15252450.
  • Mauri P, Scarpa A, Nascimbeni AC, Benazzi L, Parmagnani E, Mafficini A, Della Peruta M, Bassi C, Miyazaki K, Sorio C (July 2005). “Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers”. FASEB Journal. 19 (9): 1125–7. doi:10.1096/fj.04-3000fje. PMIDΒ 15985535.
  • GrΓΈnborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A, Pandey A (January 2006). “Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach”. Molecular & Cellular Proteomics. 5 (1): 157–71. doi:10.1074/mcp.M500178-MCP200. PMIDΒ 16215274.
  • Guo J, Cheng H, Zhao S, Yu L (January 2006). “GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases”. FEBS Letters. 580 (2): 581–4. doi:10.1016/j.febslet.2005.12.076. PMIDΒ 16406369.
  • Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, Schreiber M, Jechlinger M, Beug H (September 2006). “ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells”. Cancer Cell. 10 (3): 227–39. doi:10.1016/j.ccr.2006.07.020. PMIDΒ 16959614.