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FAT (gene)
Introduction
FAT tumor suppressor homolog 1 (Drosophila), also known as FAT, is a human gene.[1]
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.[1]
Further reading
Further reading
- Dunne J, Hanby AM, Poulsom R; et al. (1996). “Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule”. Genomics. 30 (2): 207–23. PMID 8586420.
- Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. PMID 8889548.
- Matsuyoshi N, Tanaka T, Toda K, Imamura S (1997). “Identification of novel cadherins expressed in human melanoma cells”. J. Invest. Dermatol. 108 (6): 908–13. PMID 9182820.
- Matsuyoshi N, Imamura S (1997). “Multiple cadherins are expressed in human fibroblasts”. Biochem. Biophys. Res. Commun. 235 (2): 355–8. doi:10.1006/bbrc.1997.6707. PMID 9199196.
- Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). “Shotgun sequencing of the human transcriptome with ORF expressed sequence tags”. Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Brandenberger R, Wei H, Zhang S; et al. (2005). “Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation”. Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Tanoue T, Takeichi M (2004). “Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact”. J. Cell Biol. 165 (4): 517–28. doi:10.1083/jcb.200403006. PMID 15148305.
- Suzuki Y, Yamashita R, Shirota M; et al. (2004). “Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions”. Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
- Wu Q (2005). “Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes”. Genetics. 169 (4): 2179–88. doi:10.1534/genetics.104.037606. PMID 15744052.
- Magg T, Schreiner D, Solis GP; et al. (2005). “Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus”. Exp. Cell Res. 307 (1): 100–8. doi:10.1016/j.yexcr.2005.03.006. PMID 15922730.
- Blair IP, Chetcuti AF, Badenhop RF; et al. (2006). “Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele”. Mol. Psychiatry. 11 (4): 372–83. doi:10.1038/sj.mp.4001784. PMID 16402135.
- Schreiner D, Müller K, Hofer HW (2006). “The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins”. FEBS Lett. 580 (22): 5295–300. doi:10.1016/j.febslet.2006.08.079. PMID 16979624.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Nakaya K, Yamagata HD, Arita N; et al. (2007). “Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array”. Oncogene. 26 (36): 5300–8. doi:10.1038/sj.onc.1210330. PMID 17325662.
- Braun GS, Kretzler M, Heider T; et al. (2007). “Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells”. J. Biol. Chem. 282 (31): 22823–33. doi:10.1074/jbc.M701758200. PMID 17500054.