Health Dictionary
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FBXW10
Introduction
F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.[1][2][3]
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM][3]
References
References
- ↑ Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). “Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat”. Genomics. 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID 9787083.
- ↑ Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995). “Single test for two hereditary neuropathies, CMT1A and HNPP”. Clin Chem. 41 (10): 1534–5. PMID 7586531.
- ↑ 3.0 3.1 “Entrez Gene: FBXW10 F-box and WD repeat domain containing 10”.
Further reading
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Jin J, Cardozo T, Lovering RC, et al. (2005). “Systematic analysis and nomenclature of mammalian F-box proteins”. Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). “Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs”. Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.