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FCGR1A
Introduction
High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.[1][2][3]
Interactions
Interactions
FCGR1A has been shown to interact with FCAR.[4] The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif.[5]
References
References
- ā Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). “The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21”. Cytogenetics and Cell Genetics. 73 (3): 157ā63. doi:10.1159/000134330. PMIDĀ 8697799.
- ā Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). “Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1”. Cytogenetics and Cell Genetics. 82 (1ā2): 71ā4. doi:10.1159/000015067. PMIDĀ 9763663.
- ā “Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)”.
- ā Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (Dec 1995). “Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association”. The Journal of Biological Chemistry. 270 (50): 29781ā7. doi:10.1074/jbc.270.50.29781. PMIDĀ 8530370.
- ā The function of FcĪ³ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology
Further reading
Further reading
- Monteiro RC, Van De Winkel JG (2003). “IgA Fc receptors”. Annual Review of Immunology. 21: 177ā204. doi:10.1146/annurev.immunol.21.120601.141011. PMIDĀ 12524384.
- Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (Aug 1992). “Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products”. The Journal of Biological Chemistry. 267 (22): 15692ā700. PMIDĀ 1379234.
- Benech PD, Sastry K, Iyer RR, Eichbaum QG, Raveh DP, Ezekowitz RA (Oct 1992). “Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure”. The Journal of Experimental Medicine. 176 (4): 1115ā23. doi:10.1084/jem.176.4.1115. PMCĀ 2119393. PMIDĀ 1402657.
- Porges AJ, Redecha PB, Doebele R, Pan LC, Salmon JE, Kimberly RP (Nov 1992). “Novel Fc gamma receptor I family gene products in human mononuclear cells”. The Journal of Clinical Investigation. 90 (5): 2102ā9. doi:10.1172/JCI116094. PMCĀ 443278. PMIDĀ 1430234.
- van de Winkel JG, Ernst LK, Anderson CL, Chiu IM (Jul 1991). “Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene”. The Journal of Biological Chemistry. 266 (20): 13449ā55. PMIDĀ 1830050.
- Eizuru Y, Minamishima Y (1989). “Induction of Fc (IgG) receptor(s) by simian cytomegaloviruses in human embryonic lung fibroblasts”. Intervirology. 29 (6): 339ā45. doi:10.1159/000150065. PMIDĀ 2852656.
- Allen JM, Seed B (Jan 1989). “Isolation and expression of functional high-affinity Fc receptor complementary DNAs”. Science. 243 (4889): 378ā81. doi:10.1126/science.2911749. PMIDĀ 2911749.
- Allen JM, Seed B (Dec 1988). “Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI)”. Nucleic Acids Research. 16 (24): 11824. doi:10.1093/nar/16.24.11824. PMCĀ 339124. PMIDĀ 2974947.
- Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD (Jul 1994). “The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI”. Experimental Hematology. 22 (7): 599ā606. PMIDĀ 7516890.
- Valerius T, Repp R, de Wit TP, Berthold S, Platzer E, Kalden JR, Gramatzki M, van de Winkel JG (Aug 1993). “Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy”. Blood. 82 (3): 931ā9. PMIDĀ 7687898.
- Wang AV, Scholl PR, Geha RS (Sep 1994). “Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn”. The Journal of Experimental Medicine. 180 (3): 1165ā70. doi:10.1084/jem.180.3.1165. PMCĀ 2191633. PMIDĀ 8064233.
- Takai S, Kasama M, Yamada K, Kai N, Hirayama N, Namiki H, Taniyama T (Jan 1994). “Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization”. Human Genetics. 93 (1): 13ā5. doi:10.1007/BF00218905. PMIDĀ 8270248.
- Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (Dec 1995). “Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association”. The Journal of Biological Chemistry. 270 (50): 29781ā7. doi:10.1074/jbc.270.50.29781. PMIDĀ 8530370.
- De SK, Venkateshan CN, Seth P, Gajdusek DC, Gibbs CJ (Mar 1998). “Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines”. Blood. 91 (6): 2108ā17. PMIDĀ 9490697.
- Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL (Nov 1998). “Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)”. Journal of Immunology. 161 (10): 5555ā63. PMIDĀ 9820532.
- Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (Nov 1998). “The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes”. European Journal of Immunology. 28 (11): 3423ā34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMIDĀ 9842885.
- Gorgani NN, Altin JG, Parish CR (Aug 1999). “Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes”. International Immunology. 11 (8): 1275ā82. doi:10.1093/intimm/11.8.1275. PMIDĀ 10421785.
- Tridandapani S, Lyden TW, Smith JL, Carter JE, Coggeshall KM, Anderson CL (Jul 2000). “The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells”. The Journal of Biological Chemistry. 275 (27): 20480ā7. doi:10.1074/jbc.M909462199. PMIDĀ 10781611.