Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

FGF3 (gene)

Introduction

Fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog), also known as FGF3, is a human gene.[1]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.[1]

References

References

  1. ↑ 1.0 1.1 “Entrez Gene: FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)”.
Further reading

Further reading

  • Represa J, LeΓ³n Y, Miner C, Giraldez F (1991). “The int-2 proto-oncogene is responsible for induction of the inner ear”. Nature. 353 (6344): 561–3. doi:10.1038/353561a0. PMIDΒ 1922362.
  • Brookes S, Smith R, Casey G; et al. (1989). “Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells”. Oncogene. 4 (4): 429–36. PMIDΒ 2470007.
  • Casey G, Smith R, McGillivray D; et al. (1987). “Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene”. Mol. Cell. Biol. 6 (2): 502–10. PMIDΒ 3023852.
  • Mansour SL, Goddard JM, Capecchi MR (1993). “Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear”. Development. 117 (1): 13–28. PMIDΒ 8223243.
  • Ornitz DM, Xu J, Colvin JS; et al. (1996). “Receptor specificity of the fibroblast growth factor family”. J. Biol. Chem. 271 (25): 15292–7. PMIDΒ 8663044.
  • Galdemard C, Yamagata H, Brison O, Lavialle C (2000). “Regulation of FGF-3 gene expression in tumorigenic and non-tumorigenic clones of a human colon carcinoma cell line”. J. Biol. Chem. 275 (23): 17364–73. doi:10.1074/jbc.M909316199. PMIDΒ 10749884.
  • Reimers K, Antoine M, Zapatka M; et al. (2001). “NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth”. Mol. Cell. Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMIDΒ 11438656.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMIDΒ 12477932.
  • Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). “Functional phylogeny relates LET-756 to fibroblast growth factor 9”. J. Biol. Chem. 279 (38): 40146–52. doi:10.1074/jbc.M405795200. PMIDΒ 15199049.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMIDΒ 15489334.
  • Antoine M, Reimers K, Wirz W; et al. (2006). “Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2”. Biochem. Biophys. Res. Commun. 338 (2): 1248–55. doi:10.1016/j.bbrc.2005.10.079. PMIDΒ 16263090.
  • Tekin M, Hişmi BO, Fitoz S; et al. (2007). “Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia”. Am. J. Hum. Genet. 80 (2): 338–44. doi:10.1086/510920. PMIDΒ 17236138.
  • Riley BM, Mansilla MA, Ma J; et al. (2007). “Impaired FGF signaling contributes to cleft lip and palate”. Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4512–7. doi:10.1073/pnas.0607956104. PMIDΒ 17360555.

Template:WikiDoc Sources