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FIBP
Introduction
Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.[1][2]
Function
Function
Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.[2]
References
References
- β 1.0 1.1 Kolpakova, E; WiedΕocha, A; Stenmark, H; Klingenberg, O; Faines, PO; Olsnes, S (15 November 1998). “Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor”. Biochem. J. 336 (1): 213β22. doi:10.1042/bj3360213. PMCΒ 1219860. PMIDΒ 9806903.
- β 2.0 2.1 “Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein”.
Further reading
Further reading
- Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1β2): 171β4. doi:10.1016/0378-1119(94)90802-8. PMIDΒ 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1β2): 149β56. doi:10.1016/S0378-1119(97)00411-3. PMIDΒ 9373149.
- Kolpakova E, Frengen E, Stokke T, Olsnes S (2000). “Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein”. Biochem. J. 352 (3): 629β35. doi:10.1042/0264-6021:3520629. PMCΒ 1221498. PMIDΒ 11104667.
- Tassi E, Al-Attar A, Aigner A, Swift MR, McDonnell K, Karavanov A, Wellstein A (2001). “Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein”. J. Biol. Chem. 276 (43): 40247β53. doi:10.1074/jbc.M104933200. PMIDΒ 11509569.
- Skjerpen CS, Nilsen T, Wesche J, Olsnes S (2002). “Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity”. EMBO J. 21 (15): 4058β69. doi:10.1093/emboj/cdf402. PMCΒ 126148. PMIDΒ 12145206.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O’Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMCΒ 1847948. PMIDΒ 17353931.