Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
FLT1
Introduction
Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), also known as FLT1, is a human gene.
Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM][1]
References
References
Further reading
Further reading
- Petrova TV, Makinen T, Alitalo K (1999). “Signaling via vascular endothelial growth factor receptors”. Exp. Cell Res. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
- Sato Y, Kanno S, Oda N; et al. (2000). “Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction”. Ann. N. Y. Acad. Sci. 902: 201–5, discussion 205–7. PMID 10865839.
- Boyd AW, Lackmann M (2002). “Signals from Eph and ephrin proteins: a developmental tool kit”. Sci. STKE. 2001 (112): RE20. doi:10.1126/stke.2001.112.re20. PMID 11741094.
- Luttun A, Tjwa M, Carmeliet P (2003). “Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders”. Ann. N. Y. Acad. Sci. 979: 80–93. PMID 12543719.
- Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA (2005). “Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia”. Pediatr. Res. 57 (5 Pt 2): 1R–7R. doi:10.1203/01.PDR.0000159567.85157.B7. PMID 15817508.
- Shibuya M (2007). “Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis”. Angiogenesis. 9 (4): 225–30, discussion 231. doi:10.1007/s10456-006-9055-8. PMID 17109193.
- Widmer M, Villar J, Benigni A; et al. (2007). “Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review”. Obstetrics and gynecology. 109 (1): 168–80. doi:10.1097/01.AOG.0000249609.04831.7c. PMID 17197602.
- López-Novoa JM (2007). “Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia”. Nephrol. Dial. Transplant. 22 (3): 712–4. doi:10.1093/ndt/gfl768. PMID 17210583.