Health Dictionary
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FOLFIRI
Introduction
Overview
Overview
FOLFIRI is a chemotherapy regimen for treatment of colorectal cancer, made up of the drugs
- FOL – folinic acid (leucovorin)
- F – fluorouracil (5-FU)
- IRI – irinotecan (Camptosar)
The regimen consists of:
- Irinotecan (180 mg/m² IV over 90 minutes) concurrently with folinic acid (400 mg/m² [or 2 x 250 mg/m²] IV over 120 minutes).
- Followed by fluorouracil (400-500 mg/m² IV bolus) then fluorouracil (2400-3000mg/m² intravenous infusion over 46 hours).
This cycle is typically repeated every two weeks.
The dosages shown above may vary from cycle to cycle.